Best Manuka Honey – New Zealand

Tag: Manuka honey anti-inflammatory natural remedy

  • Manuka Honey A Natural Anti-Inflammatory for Skin Conditions

    Manuka Honey A Natural Anti-Inflammatory for Skin Conditions

    Table of Contents

    Introduction

    Manuka honey (MH) is a complex nutritional material known for its antimicrobial, antioxidant, and anti-inflammatory properties. It has been used for centuries as a natural remedy for various ailments. Recent studies have revealed that MH contains potential AhR (aryl hydrocarbon receptor) ligands, including indoles. The AhR is a ligand-dependent transcription factor that plays a crucial role in regulating skin homeostasis and inflammation. This article explores the hypothesis that MH’s anti-inflammatory effects are mediated, at least partially, through AhR activation.

    AhR and Skin Homeostasis

    The aryl hydrocarbon receptor (AhR) is a transcription factor that regulates skin homeostasis. Activation of AhR by physiological ligands, such as indoles derived from tryptophan metabolism, leads to the expression of cytochrome P450 (CYP) enzymes, including CYP1A1. Animal models and clinical samples of psoriasis and atopic dermatitis have shown that AhR activation has anti-inflammatory effects.

    MH and its Potential AhR Ligands

    Manuka honey (MH) is a unique substance with various health benefits. It has been found to possess antimicrobial, antioxidant, and anti-inflammatory activity. Previous research has shown that MH can downregulate interleukin (IL)-4-induced CCL26 expression in keratinocytes, indicating its potential as an anti-inflammatory agent. Recent studies have also identified potential AhR ligands in MH, including indoles derived from microbial metabolism of tryptophan.

    The Role of AhR Activation in MH’s Anti-Inflammatory Effect

    To investigate the role of AhR activation in MH’s anti-inflammatory effect, HaCaT keratinocytes, either stably transfected with an empty vector (EV-HaCaT) or in which AhR had been stably silenced (AhR-silenced HaCaT), were treated with 2% MH for 24 hours. Gene expression was measured using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). The results showed a significant upregulation of CYP1A1 in EV-HaCaTs, which was reduced in AhR-silenced cells. Pretreatment with the AhR antagonist CH223191 abrogated this effect.

    Confirmation of AhR Activation in NHEKs

    Similar findings were observed in primary normal human epithelial keratinocytes (NHEKs) treated with 2% MH. The upregulation of CYP1A1 expression was significantly reduced when AhR was silenced, and pretreatment with CH223191 inhibited the effect of MH. These results confirm the role of AhR activation in MH’s anti-inflammatory effect.

    In Vivo Evidence of AhR Activation by MH

    To further investigate the in vivo effects of MH on AhR activation, Cyp1a1Cre × R26ReYFP reporter mice were treated with pure MH epicutaneously. The results showed a significant induction of CYP1A1 expression compared to Vaseline, providing further evidence of AhR activation by MH.

    Time-Dependent Activation of AhR by MH

    In addition to direct activation, MH was found to indirectly activate AhR in HaCaT keratinocytes. Treatment with 2% MH initially decreased baseline CYP1A1 enzymatic activity at 3 and 6 hours but increased it after 12 hours. This suggests that MH may activate AhR through both direct and indirect means.

    AhR Activation Mediates MH’s Anti-Inflammatory Effects

    The downregulation of IL-4-induced CCL26 mRNA and protein by MH was found to be dependent on AhR activation. In AhR-silenced HaCaTs and those pretreated with CH223191, the anti-inflammatory effect of MH on CCL26 expression was abrogated. This further supports the hypothesis that MH’s anti-inflammatory effect is mediated, at least partially, through AhR activation.

    AhR-Dependent Upregulation of FLG Expression

    MH was also found to upregulate filaggrin (FLG) expression in NHEKs in an AhR-dependent manner. Filaggrin is an essential protein involved in maintaining skin barrier function. The upregulation of FLG expression by MH further highlights its potential as a natural remedy for skin inflammatory conditions.

    Clinical Implications of MH’s AhR-Activating Properties

    The AhR-activating properties of MH have broader clinical implications for a range of skin inflammatory conditions. MH’s anti-inflammatory effects, mediated through AhR activation, make it a promising natural treatment option for conditions such as psoriasis and atopic dermatitis. Further research is needed to explore the full potential of MH in managing these skin conditions.

    In conclusion, MH’s activation of AhR, both in vitro and in vivo, provides a mechanism for its anti-inflammatory effects. The AhR-activating properties of MH could have significant clinical implications for various skin inflammatory conditions. With its natural antimicrobial, antioxidant, and anti-inflammatory activity, MH holds promise as a therapeutic agent for promoting skin homeostasis and alleviating inflammation.

    Keywords: manuka honey anti-inflammatory

  • Manuka Honey The Potent Natural Remedy with Anti-Inflammatory Benefits

    Manuka Honey The Potent Natural Remedy with Anti-Inflammatory Benefits

    Table of Contents

    Introduction

    As the saying goes, “an apple a day keeps the doctor away”, but what if you could replace that apple with a spoonful of manuka honey? Manuka honey, the sweet nectar harvested from the manuka tree in New Zealand, is a potent natural remedy that has been used for centuries. It’s now becoming more and more popular because it has been scientifically proven to have a variety of health benefits. In fact, it’s recognized as one of the most powerful superfoods on the planet. In this article, we’ll explore the health benefits of manuka honey and why it’s the best manuka honey NZ has to offer.

    What makes manuka honey so special?

    Manuka honey is unique because it has an exceptionally high concentration of a compound called methylglyoxal (MGO). MGO is a potent antibacterial agent that makes manuka honey incredibly effective at treating wounds and fighting bacteria. The higher the MGO rating of the honey, the more potent its antibacterial properties.

    The majority of honey has peroxide antibacterial properties, which are created naturally during the process of making honey. However, these properties are unstable and can be destroyed by heat, light, and exposure to water. MGO, on the other hand, is a stable compound that is not affected by heat, light, or water. This makes manuka honey a particularly potent tool for healing wounds, treating infections, and improving overall health.

    Health benefits of manuka honey

    1. Improves digestive health

    Manuka honey contains prebiotics, which promote the growth of good bacteria in the gut. It can also help reduce inflammation, bloating, and other digestive issues. Manuka honey is particularly effective at treating Helicobacter pylori infections, which are a common cause of ulcers.

    2. Boosts immunity

    The antibacterial properties of manuka honey make it a powerful immune-booster. It can help fight off infections, viruses, and bacteria that can cause illness. It’s especially helpful during cold and flu season, as it can help reduce the severity and duration of symptoms.

    3. Soothes sore throats and coughs

    Manuka honey has long been used as a natural remedy for sore throats and coughs. Its antibacterial and anti-inflammatory properties can help reduce inflammation and irritation in the throat. It can also help soothe and coat the throat, providing relief from coughs and other respiratory symptoms.

    4. Improves wound healing

    Manuka honey is a fantastic natural remedy for wound healing. Its antibacterial properties can help prevent infection, while its anti-inflammatory properties can help reduce pain and inflammation. Additionally, manuka honey has been shown to help promote the growth of new tissue, which can help speed up the healing process.

    5. Helps relieve allergic symptoms

    Manuka honey can help reduce the severity of allergic symptoms, such as itching, sneezing, and watery eyes. It contains anti-inflammatory properties, which can help reduce the body’s reaction to allergens. Additionally, manuka honey can help boost immunity, which can help reduce the frequency and severity of allergic reactions.

    The best manuka honey NZ has to offer

    When it comes to purchasing manuka honey, it’s essential to choose a high-quality product. The most surefire way to ensure the quality of your manuka honey is to choose a product that has been independently tested and certified. The Unique Manuka Factor (MGO) rating is a measure of the potency of manuka honey. A higher MGO rating means that the manuka honey has a higher concentration of non-peroxide activity’(NPA) or UMF and is therefore more potent. The best manuka honey NZ has to offer will have an MGO rating of at least 250+.

    Another thing to consider when purchasing manuka honey is whether it has been sustainably produced. Look for a company that practices sustainable beekeeping and supports ethical practices.

    Conclusion

    Manuka honey is a potent natural remedy that has been used for centuries. Now, thanks to modern scientific research, we have a better understanding of its health benefits. From improving digestive health and wound healing to boosting immunity and relieving allergic symptoms, manuka honey is a true superfood. And when it comes to choosing the best manuka honey NZ has to offer, look for a product that has been independently tested and certified, has an MGO rating of at least 250+, and is sustainably produced. Manuka honey anti-inflammatory properties make it a valuable addition to your daily routine for overall health and wellness.